Reactive cysteine residues undergoing posttranslational oxidative modifications regulate enzymatic activities and signaling pathways. Oxidoreductases, namely glutaredoxins and thioredoxins, reduce oxidized cysteines. These thiol switches control many relevant cellular processes, such as differentiation. Disturbed redox regulation is conected to many diseases. Our research aims in the identification of new thiol switches controlling differentiation as well as disease initiation and progression.
Latest Reviews
Berndt, C., Wilms, C., Gellert, M., and Lillig, C.H.
Structure-function relationships discriminating between mono- and dithiol Glutaredoxins.
in: „Redox Chemistry and Biology of Thiols“, Alvarez, Comini, Salinas, Eds., Elsevier (2021)
Wolf, C., López del Amo, V., Arndt, S., Bueno, D., Tenzer, S., Hanschmann, E.M., Berndt, C., and Methner, A.
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery.
Cells 9: 815 (2020)
Our past and current research was/is funded by:
