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Our publications

full text of most of the publications are available at

original work and review articles

Ito, J., Nakamura, T., Toyama, T., Chen, D., Berndt, C., Poschmann, G., Santos Dias Mourao, A., Doll, S., Suzuki, M., Zhang, W., Zheng, J., Trümbach, D., Yamada, N., Ono, K., Yazaki, M., Kawai, Y., Arisawa, M., Ohsaki, Y., Shirakawa, H., Wahida, A., Proneth, B., Saito, Y., Nakagawa, K., Mishima, E, and Conrad, M.
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.
Mol. Cell 84: 1-16 (2024)

Du, R., Sanin, A.Y., Shi, W., Huang, B., Nickel, A.-C., Vargas-Toscano, A., Huo, S., Nickl-Jockschat, T., Dumitru, C.A., Hu, W., Duan, S., Sandalcioglu, I.E., Croner, R.S., Alcaniz, J., Walther, W., Berndt, C., and Kahlert D.U.
Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo.
Front. Pharmacol. 15: 1468920 (2024)

Berndt, C., Alborzinia, H., Amen, V.S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C.M., Birsoy, K., Böttcher, J.P., Brabletz, S., Brabletz, T., Brown, A.R., Brüne, B., Bulli, G., Bruneau, A., Chen, Q., DeNicola, G.M., Dick, T.P., Distéfano, A., Dixon, S.J., Engler, J.B., Esser-von Bieren, J., Fedorova, M., Friedmann Angeli, J.P., Friese, M.A., Fuhrmann, D.C., García-Sáez, A.J., Garbowicz, K., Götz, M., Gu, W., Hammerich, L., Hassannia, B., Jiang, X., Jeridi, A., Kang, Y.P., Kagan, V.E., Konrad, D.B., Kotschi, S., Lei, P., Le Tertre, M,. Lev, S., Liang, D., Linkermann, A., Lohr, C., Lorenz, S., Luedde, T., Methner, A., Michalke, B., Milton, A.V., Min, J., Mishima, E., Müller, S., Motohashi, H., Muckenthaler, M.U., Murakami, S., Olzmann, J.A., Pagnussat, G., Pan, Z., Papagiannakopoulos, T., Pedrera Puentes, L., Pratt, D.A., Proneth, B., Ramsauer, L., Rodriguez, R., Saito, Y., Schmidt, F., Schmitt, C., Schulze, A., Schwab, A., Schwantes, A., Soula, M., Spitzlberger, B., Stockwell, B.R., Thewes, L., Thorn-Seshold, O., Toyokuni, S., Tonnus, W., Trumpp. A., Vandenabeele, P., Vanden Berghe, T., Venkataramani, V., Vogel, F.C.E., von Karstedt, S., Wang, F., Westermann, F., Wientjens, C., Wilhelm, C., Wölk, M., Wu, K., Yang, X., Yu, F., Zou, Y., and Conrad, M.
Ferroptosis in health and disease.
Redox Biol. 75: 103211 (2024)

Hamre, K., Zhang W., Hoff Austgulen, M., Mykkeltvedt, E., Yin, P., Berntssen, M., Espe, M., and Berndt, C.
Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny.
Biochim. Biophys. Acta-Gen. Subjects 1868: 130603 (2024)

Funk, L.-M., Poschmann, G., Chari, A., Rabe von Pappenheim, F., Stegmann, K.-M., Dickmanns, A., Eulig, N., Wensien, M., Paknia, E., Heyne, G., Penka, E., Pearson, A.R., Berndt, C., Fritz, T., Bazzi, S., Uranga, J., Mata, R.M., Dobbelstein, M., Hilgenfeld, R., Curth, U., and Tittmann, K.
Redox regulation of the SARS-CoV-2 main protease provides new oppotunities for drug design.
Nat. Commun. 15: 411 (2024)

Nguyen, L., Westerhoff, M., Thewes, L., Wruck, W., Reichert, A.S., Berndt, C., and Adjaye, J.
JNK signaling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis.
Cells 12: 297 (2023)

Pfeuffer, S., Müntefering, T., Rolfes, L., Straten, F.A., Eichler, S., Gruchot, J., Dobelmann, V., Prozorovski, T., Görg, B., Vucur, M., Berndt, C., Küry, P., Ruck, T., Bittner, S., Bettenworth, D., Budde, T., Lüdde, T., and Meuth, S.G.
Deficiency of the two-pore potassium channel KCNK9 impairs intestinal epithelial cell survival and aggravates dextran sodium sulfate-induced colitis.
Cell. Mol. Gastroenterol. Hepatol. 14: 1199-1211 (2022)

Wilms, C., Lepka, K., Häberlein, F., Edwards, S., Felsberg, J., Pudelko, L., Lindenberg, T.T., Poschmann, G., Qing, N., Volbracht, K., Prozorovski, T., Meuth, S.G., Kahlerth, U.D., Remke, M., Aktas, O., Reifenberger, G., Bräutigam, L, Odermatt, B., and Berndt, C.
Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: enzymatic Taoism.
Redox Biol. 49:102221 (2022)

Sun, Y., Berleth, N., Wu, W., Schlütermann, D., Deitersen, D., Stuhldreier, F., Berning, L., Friedrich, A., Akguen, S., Mendiburo, M., Wesselborg, S., Conrad, M., Berndt, C., and Stork, B.
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Cell Death Dis. 12: 1028 (2021)

Berndt, C., Loϊck, C., Rouhier, N., and Mühlenhoff, U.
Glutaredoxins with Iron-Sulphur Clusters in Eukaryotes - Structure, Function and Impact on Disease.
Biochim. Biophys. Acta-Bioenergetics 1862: 148317 (2021)

Trnka, D., Engelke, A.D., Gellert, M., Moseler, A., Hossain, M.F., Lindenberg, T.T., Pedroletti, L., Odermatt, B., de Souza, J.V., Boronowska, A.K., Dick, T.P., Mühlenhoff, U., Meyer, A.J., Berndt, C., and Lillig, C.H.
Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins.
Nat. Commun. 11: 3445 (2020)

Hanschmann, E.M., Berndt, C., Hecker, C., Garn, H., Bertrams, W., Lillig, C.H., and Hudemann, C.
Glutaredoxin 2 reduces asthma-like acute airway inflammation in mice.
Front. Immunol. 11: 561721 (2020)

Wolf, C., López del Amo, V., Arndt, S., Bueno, D., Tenzer, S., Hanschmann, E.M., Berndt, C., and Methner, A.
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery.
Cells 9: 815 (2020)

Dietrich, M., Koska, V., Hecker, C., Göttle, P., Hilla, A.M., Heskamp, A., Lepka, K., Issberner, A., Hallenberger, A., Baksmeier, C., Steckel, J., Balk, L., Knier, B., Korn, T., Havla, J., Martinez-Lapiscina, E.H., Solá, N., Manogaran, P., Olbert, E.D., Schippling, S., Cruz-Harranz, A., Yiu, H., Button, J., Caldito, N.G., von Gall, C., Mausberg, A.K., Stettner, M., Zimmermann, H., Paul, F., Brandt, A.U., Küry, P., Goebels, N., Aktas, O., Berndt, C., Saidha, S., Green, A.J., Calabresi, P.A., Fischer, D., Hartung, H.P., and Albrecht, P.
Protective effects of 4-Aminopyridine in experimental optic neuritis and multiple sclerosis.
Brain 143: 1127-1143 (2020)

Prozorovski, T., Ingwersen, J., Lukas, D., Göttle, P., Graf, J., Schneider, R., Franke, K., Schumacher, S., Britsch, S., Hartung, H.-P., Küry, P., Berndt, C., and Aktas, O.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Neurosci. Lett. 704: 116-125 (2019)

Walter, S., Jumpertz, T., Hüttenrauch, M., Ogorek, I., Gerber, H., Storck, S., Zampar, S., Dimitrov, M., Lehmann, S., Lepka, K., Berndt, C., Wiltfang, J., Becker-Pauly, C., Beher, D., Pietrzik, C.U., Fraering, P.C., Wirths, O., and Weggen, S.
The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer´s disease.
Acta Neuropathologica 137: 239-257 (2019)

Dietrich, M., Helling, N., Hilla, A., Heskamp, A., Issberner, A., Hildebrandt, T., Kohne, Z., Küry, P., Berndt, C., Aktas, O., Fischer, D., Hartung, H.-P., and Albrecht, P.
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
J. Neuroinflammation 15: 71 (2018)

Ingold, I., Berndt, C., Schmitt, S., Doll, S., Poschmann, G., Buday, K., Roveris, A., Peng, X., Portos Freita, F., Seibt, T., Mehr, L., Aichler, M., Walch, A., Lamp, D., Jastroch, M., Miyamoto, S., Wurst, W., Ursini, F., Arnér, E.S.J., Fradejas-Villar, N., Schweizer, U., Zischka, H., Friedmann Angeli, J.P., and Conrad, M.
Selenium utilization by GPX4is required to prevent hydroperoxide-induced ferroptosis.
Cell 172: 409-422 (2018)

Berndt, C., and Lillig, C.H.
Glutathione, Glutaredoxins, and iron
Antioxid. Redox Signal. 27: 1235-1251 (2017)

Sies, H., Berndt, C., and Jones D.P.
Oxidative Stress
Annu. Rev. Biochem. 86: 715-748 (2017)

Lepka, K., Volbracht, K., Bill, E., Schneider, R., Rios, N., Hildebrandt, T., Ingwersen, J., Prozorovski, T., Lillig, C.H., van Horssen, J., Steinman, L., Hartung, H.-P., Radi, R., Holmgren, A., Aktas, O., and Berndt, C.
Iron-sulfur Glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide released from activated microglia.
Glia 65: 1521-1534 (2017)

Egea J., Fabregat, I., Frapart, Y.M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U.G., Lopez, M.G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C.B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M.M., Barbosa, R.M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S.P., Brito, P.M., Carrara, G., Casas, A.I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke,M.S., Costa, G.J., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec–Butuner, B., Dias, I., Dan Dunn, J., Edson, A.J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A.S., Fladmark, K.S., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J.A., Kalyanaraman, B., Kaminskyy,D., Karbaschi, M., Kleanthous, M., Klotz, L.O., Korac, B., Sami Korkmaz, K., Koziel, R., Kračun, D., Krause, K.H., Křen, V., Krieg, T., Laranjinha,J., Lazou,A., Li, H., Martínez-Ruiz,A., Matsui,R., McBean, G.J., Meredith, S.P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović,M., Monsalve, M., Mouthuy, P.A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I.T.N., Oelze, M., Oliveira, N.G., Palmeira, C.M., Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot,F., Phylactides, M., Pircalabioru, G.G., Pitt, A.R., Poulsen, H.E., Prieto, I., Rigobello, M.P., Robledinos-Antón, N., Rodríguez-Mañas, L., Rolo, A.P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G.L., Soldati, T., Sousa, B.C., Spickett, C.M., Stancic, A., Stasia, M.J., Steinbrenner, H., Stepanić,V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., Varisli, L., Veal, E.A., Yalçın, S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R.M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H.H.H.W., Di Lisa, F., and Daiber, A.
Position paper by the EU-ROS consortium on RONS in health and disease.
European Contribution to the study of ROS: A Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS)
Redox Biol. 13: 94-162 (2017)

Lepka, K., Berndt, C., Hartung, H.P., and Aktas, O.
Redox events as modulators of neuroinflammatory diseases
Front. Cell Dev. Biol. 4: 63 (2016)

Schneider, R., Koop, B., Schröter, F., Cline, J., Ingwersen, J., Berndt, C., Hartung, H.P., Aktas, O., and Prozorovski, T.
Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis.
Mol. Neurodegen. 11: 53 (2016)

Bräutigam, L., Pudelko, L., Jemth, A.S., Gad, H., Narwal, M., Gustafsson, R., Karsten, S., Homan, E., Berndt, C., Warpman-Berglund, U., Stenmark, P., and Helleday, T.
Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition.
Cancer Res. 76: 2366-2375 (2016)

Gascon, S., Murenu, E., Maserdotti, G., Ortega, F., Russo, G.L., Petrik, D., Deshpande, A., Heinrich, C., Karow, M., Robertson, S., Schroder, T., Beckers, J., Irmler, M., Berndt, C., Angeli, J.F., Conrad, M., Berninger, B., and Götz, M.
Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming.
Cell Stem Cell 18: 396-409 (2016)

Moseler, A., Aller, I., Wagner, S., Nietzel, T., Przbyla-Toscano, Mühlenhoff, U., Lill, R., Berndt, C., Rouhier, N., Schwarzländer, M., and Meyer, A.
The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in Arabidopsis thaliana.
Proc. Natl. Acad. Sci. USA 112: 13735-13740 (2015)

Hildebrandt, T., Knuesting, J., Berndt, C., Morgan, B., and Scheibe, R.
Cystosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?
Biol. Chem. 396: 523-537 (2015)

Berndt, C., and Lillig, C.H.
Redox regulation of differentiation and de-differentiation
Biochim. Biophys. Acta-General subjects 1850: 1467-1468 (2015)

Berndt, C., Schwenn, J.D., and Lillig, C.H.
The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric complementarity.
Chem. Sci. 6: 7049-7058 (2015)

Gellert, M., Hanschmann, E.M., Lepka, K., Berndt, C., and Lillig, C.H.
Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation.
Biochim. Biophys. Acta-General subjects 1850: 1575-1587 (2015)

Prozorovski, T., Schneider, R., Berndt, C., Hartung, H.P., and Aktas, O.
Redox-regulated fate of neural stem progenitor cells.
Biochim. Biophys. Acta-General subjects 1850: 1543-1554 (2015)

Knuesting, J., Riondet, C., Maria, C., Kruse, I., Becuwe, N., König, N., Berndt, C., Tourrette, S., Guilleminot-Montoya, Herrero, E., Gaymard, F., Balk, J., Belli, G., Scheibe, R., Reicheld, J.-P., Rouhier, N., and Rey, P.
Arabidopsis glutaredoxin S17 and its partner NF-YC11/NC2a contribute to maintenance of the shoot apical meristem under long-day photoperiod.
Plant Physiol. 167: 1643-1658 (2015)

Berndt, C.*, Lillig. C.H., Flohé, L.
Redox regulation by glutathion needs enzymes.
Front. Pharmacol. 5: 168 (2014)

Berndt, C.*, Poschmann, G., Stühler, K., Holmgren, A., and Bräutigam, L.*
Zebrafish heart development is regulated via Glutaredoxin 2 dependent migration and survival of neural crest cells.
Redox Biol. 2: 673-678 (2014)

Bräutigam, L., Jensen, L.D., Poschmann, G., Nyström, S., Bannenberg, S., Dreij, K., Lepka, K., Prozorovski, T., Montano, S.J., Aktas, O., Uhlén, P., Stühler, K., Cao, Y., Holmgren, A., and Berndt, C.
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Proc. Natl. Acad. Sci. U S A. 110: 20057-20062 (2013)

Bräutigam, L., Johansson, C., Kubsch, B., McDonough, M.A., Bill, E., Holmgren, A., and Berndt, C.
An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin.
Biochem. Biophys. Res. Commun. 436: 491-496 (2013)

Hanschmann, E.M., Godoy, J.R., Berndt, C., Hudemann, C., and Lillig, C.H.
Thioredoxins, glutaredoxins, and peroxiredoxins – molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling.
Antioxid. Redox Signal. 19: 1539-1605 (2013)

Lillig, C.H., and Berndt, C.
Cellular functions of glutathione
Biochim. Biophys. Acta-General subjects 1830: 3137-3138 (2013)

Haunhorst, P., Hanschmann, E.M., Bräutigam, L., Stehling, O., Hoffmann, B., Mühlenhoff, U., Lill, R.*, Berndt, C.*, and Lillig, C.H.*
Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.
Mol. Biol. Cell 24: 1895-1903 (2013)

Manta, B., Pavan, C., Sturlese, M., Medeiros, A., Crispo, M., Berndt, C., Krauth-Siegel, R.L., Bellanda, M., and Comini, M.A.
Iron-sulfur cluster (ISC) binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of ISC coordination and relevance for parasite infectivity.
Antioxid. Redox Signal. 19: 665-682 (2013)

Lillig, C.H., and Berndt, C.
Glutaredoxins in thiol/disulfide exchange.
Antioxid. Redox Signal. 18: 1654-1665 (2013)

Bräutigam, L., Schütte, L.D., Godoy, J.R., Prozorovski, T., Gellert, M., Hauptmann, G., Holmgren, A., Lillig, C.H., and Berndt, C.
Vertebrate-specific glutaredoxin is essential for brain development.
Proc. Natl. Acad. Sci, USA 108: 20532-20537 (2011)

Berndt, C., Kurz, T., Bannenberg, S., Jacob, R., Holmgren, A., and Brunk, U.T.
Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture.
Cancer Letters 307: 119-123 (2011)

Hoffmann, B., Uzarska, M.A., Berndt, C., Godoy, J.R., Haunhorst, P., Lill, R., Lillig, C.H., and Muhlenhoff, U.
The Multi-Domain Thioredoxin-Monothiol Glutaredoxins represents a Distinct Functional Group.
Antioxid. Redox Signal. 15: 19-30 (2011)

Berndt, C., Kurz, T., Selenius, M., Fernandes, A.P., Edgren, M.R., and Brunk,U.T.
Chelation of lysosomal iron protects against ionizing radiation.
Biochem. J. 432: 295-301 (2010)

Ceylan, S., Seidel, V., Ziebart, N., Berndt, C., Dirdjaja,N., and Krauth- Siegel, R.L.
The dithiol glutaredoxins of African trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism.
J. Biol. Chem. 285: 35224-35237 (2010)

Haunhorst, P., Berndt, C., Eitner, S., Godoy-Berthet, J.R., and Lillig, C.H.
Characterisation of human Grx3 (PICOT) as FeS protein.
Biochem. Biophys. Res. Commun. 394: 372-376 (2010)

Zahedi Avval, F., Berndt, C., Pramanik, A., and Holmgren, A.
Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).
Biochem. Biophys. Res. Commun. 379: 775-779 (2009)

Lu, J., Berndt, C., and Holmgren, A.
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.
Biochim. Biophys. Acta-General Subjects 1790: 1513-1519 (2009)

Lillig, C.H., and Berndt, C.
Preface to the special issue on redox regulation of cell function.
Biochim. Biophys. Acta-General Subjects 1780: 1169 (2008)

Lillig, C.H., Berndt, C., and Holmgren, A.
Glutaredoxin systems.
Biochim. Biophys. Acta-General Subjects 1780: 1304-1317 (2008)

Comini, M.A., Rettig, J., Dirdjaja, N., Hanschmann, E.M., Berndt, C., and Krauth-Siegel, R.L.
Monothiol Glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of african trypanosomes.
J. Biol. Chem. 283: 27785-27798 (2008)

Lönn, M.E., Hudemann, C., Berndt, C., Cherkasov, V., Capani, F., Holmgren, A., and Lillig, C.H.
Expression pattern of human glutaredoxin 2 isoforms: Identification and characterization of two testis/cancer cell-specific isoforms.
Antioxid. Redox Signal. 10: 547-558 (2008)

13
Berndt, C., Lillig, C.H., and Holmgren, A.
Glutaredoxins and Thioredoxins as facilitators of protein folding.
Biochim. Biophys. Acta-Mol. Cell Res.1783: 641-651 (2008)

Hudemann, C., Berndt, C., and Lillig, C.H.
Glutaredoxine und Eisen-Schwefel-Zentren.
Biospektrum 14: 32-35 (2008)

Su, D., Berndt, C., Fomenko, D.E., Holmgren, A., and Gladyshev, V.N.
A conserved cis-proline precludes metalbinding by the active site thiolates in members of the thioredoxin family of proteins.
Biochemistry 46: 6903-6910 (2007)

Berndt, C., Lillig, C.H., and Holmgren, A.
Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system.
Am. J. Physiol. Heart Circ. Physiol. 293: H1227-H1236 (2007)

Hashemy, I.S., Johansson, C., Berndt, C., Lillig, C.H., and Holmgren, A.
Oxidations and S-nitrosylation of cysteins in human cytosolic and mitochondrial glutaredoxins.
J. Biol. Chem. 282: 14428-14436 (2007)

Berndt, C., Hudemann, C., Hanschmann, E.M., Axelsson,R., Holmgren, A., and Lillig, C.H.
How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?
Antioxid. Redox Signal. 9: 151-157 (2007)

Lillig, C.H., Berndt, C., Vergnolle, O., Lönn, M.E., Hudemann, C., Bill, E., and Holmgren, A.
Characterization Of Human Glutaredoxin2 As New Iron-Sulfur Protein: A Possible Role As Redox Sensor.
Proc. Natl. Acad. Sci. USA 102: 8168-8173 (2005)

Fernandes, A.P., Fladvad, M., Berndt, C., Andresen, C., Lillig, C.H., Neubauer, P., Sunnerhagen, M., Holmgren, A., and Vlamis-Gardikas, A.
A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase.
J. Biol. Chem. 280: 24544-24552 (2005)

Holmgren, A., Johansson, C., Berndt, C., Lönn, M.E., Hudemann, C., and Lillig, C.H.
Thiol redox control via thioredoxin and glutaredoxin systems.
Biochem. Soc. Trans. 33: 1375-1377 (2005)

Berndt, C., Lillig, C.H., Wollenberg, M., Bill, E., Mansilla, M.C., de Mendoza, D., Seidler, A., and Schwenn, J.D.
Characterisation and Rekonstitution of a 4Fe-4S Adenylyl Sulfate/Phosphoadenylyl Sulfate Reductase from Bacillus subtilis.
J. Biol. Chem. 279: 7850-7855 (2004)

Wollenberg, M., Berndt, C., Bill, E., Schwenn, J.D., and Seidler, A.
A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins.
Eur. J. Biochem. 270: 1662-1671 (2003)

Rouhier, N., Vlamis-Gardikas, A., Lillig, C.H., Berndt, C., Schwenn, J.D., Holmgren, A., and Jacquot, J.P.
Characterisation of the Redox Properties of Poplar Glutaredoxin.
Antioxid. Redox Signal. 5: 15-22 (2003)

Lillig, C.H., Schiffmann, S., Berndt, C., Berken, A., Tischka, R., and Schwenn, J.D.
Molecular and catalytic properties of Arabidopsis thaliana adenylylsulfate-(APS)-kinase.
Arch. Biochem. Biophys. 392: 301-310 (2001)

preprints

Berndt, C.*, Hanschmann, E.M., Urbainsky, C., Jordt, L.M., Müller, S.C., Bodnar, Y., Schipper, S., Handorf, O., Nowack, R., Moulis, J.M., Schulzke, C., Schünemann, V., and Lillig, C.H.*
FeS-cluster coordination of vertebrate thioredoxins regulates suppression of hypoxia-induced factor 2a through iron regulatory protein 1.
preprint, bioRxiv, doi.org/11.101/2020.08.04.235721

Lim J.K.M., Stölting, F., Levy,T., Thewes, L., Picard, D., Tishina, S., Zhang, H.-F., Lewandowska, O., Reiff, T., Remke, M., Brägelmann, J., Beleggia, F., Berndt, C., von Karstedt, S., Reifenberger, G., Rotblat, B., and Leprivier, G.

Oncogenic RAS signaling suppresses ferroptosis via transcriptional upregulation of GCH1
preprint, bioRxiv, doi: https://doi.org/10.1101/2024.01.27.577524

Ortégon Salas, C., Bodnar, Y., Uhlenkamp, D., Schneider, K., Knaup, L., Deponte, M., Berndt, C., Lillig,C.H.L., and Gellert, M.
NADPH-dependent oxidation of CRMP2 through a MICAL1-Prx1 redox relay controls neurite outgrowth.
preprint, Research Square, doi.org/10.21203/rs.3.rs-712397/v1

published conference contributions

Fischer K., Thewes, L., Bayer, M., Meuth, S.G., Aktas, O., and Berndt, C.

Does Diroximel fumarate protect against ferrotptosis?

Glia 71: E934 (2023)

Ortegón Salas, C., Knaup, L.K., Schneider, K., Scharf, C., Berndt, C., Deponte, M., Lillig, C.H., and Gellert, M.
Receptor-induced Redox Signalling Relay – From Signal to Effector.
Free Rad. Biol. Med. 159: S118 (2020)

Dietrich, M., Koska, V., Hecker, C., Göttle, P., Hilla, A.M., Heskamp, A., Lepka, K., Issberner, A., Baksmeier, C., Steckel, J., von Gall, C., Mausberg, A.K., Stettner, M., Küry, P., Goebels, N., Aktas, O., Berndt, C., Fischer, D., Hartung, H.P., and Albrecht, P.
Neuroprotective effects of 4-aminopyridine in multiple sclerosis
Multiple Sclerosis J. 25:756-757 (2019)

Koska, V., Dietrich, M., Hecker, C., Göttle, P., Hilla, A.M., Heskamp, A., Lepka, K., Issberner, A., Baksmeier, C., Steckel, J., Balk, L., Knier, B., Korn, T., Havla, J., Martinez-Lapiscina, E.H., Solá, N., Manogaran, P., Olbert, E.D., Schippling, S., Cruz-Harranz, A., Yiu, H., Button, J., Caldito, N.G., von Gall, C., Mausberg, A.K., Stettner, M., Zimmermann, H., Paul, F., Brandt, A.U., Küry, P., Goebels, N., Aktas, O., Berndt, C., Saidha, S., Green, A.J., Calabresi, P.A., Fischer, D., Hartung, H.P., and Albrecht, P.
Neuroprotective effects of 4-aminopyridine in multiple sclerosis
Multiple Sclerosis J. 25: 208-310 (2019)

Wilms, C., Lepka, K., Pudelko, ., Bräutigam, L., Häberlein, F., Odermatt, B., Aktas, O., and Berndt, C.
Redox regulated migration of glia cells
Glia 67: E125 (2019)

Dietrich, M., Helling, N., Hilla, A., Heskamp, A., Issberner, A., Hildebrandt, T., Kohne, Z., Berndt, C., Aktas, O., Fischer, D., Hartung, H.-P., and Albrecht, P.
Evaluation of the neuroprotective properties of alpha-lipoic acid by optical coherence tomography in a model of experimental autoimmune encephalomyelitis-optic neuritis.
Multiple Sclerosis J. 23: 28-29 (2017)

Ingold, I., Berndt, C., Schmitt, S., Doll, S., Poschmann, G., Roveris, A., Peng, X., Portos Freita, F., Aichler, M., Jastroch, M., Ursini, F., Arnér, E.S.J., Fradejas-Villar, N., Schweizer, U., Zischka, H., Friedmann Angeli, J.P., and Conrad, M.
Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis.
Free Rad. Biol. Med. 112: 24 (2017)

Dietrich, M., Helling, N., Issberner, A., Hilla, A., Heskamp, A., Berndt, C., Aktas, O., Fischer, D., Hartung, H.-P., and Albrecht, P.
Optical coherence tomography fort he analysis of FTY720-mediated protection from retinal degeneration in mouse models of optic neuritis and traumatic nerve inhury.
Multiple sclerosis J. 22: 560-561 (2016)

Berndt, C., Lillig, C.H.
The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric complementarity and not by redox potential.
FEBS J 282: 110 (2015)

Gellert, M., Berndt, C., Deponte, M., Lillig, C.H.
Redox control of cytosceletal dynamics: toggling the thiol switch in CRMP2.
FEBS J 282: 115 (2015)

Lepka, K., Volbracht, K., Schaberg, E., Hartung, H.P., Goebels, N., Aktas, O., and Berndt, C.
Glutaredoxin 2 increases oligodendroglial capacity for regeneration after neuroinflammatory damage.
Glia 63: E421 (2015)

Klose, J., Görg, B., Berndt, C., Häussinger, D., Aktas, O., and Prozorovski, T.
Protein oxidative damage in hippocampus in a mouse model of acute hyperammonemia.
J. Clinic. Biochem. Nutr. 54: S97 (2014)

Lepka, K., Volbracht, K., Voevodskaya, N., Bill., E., Hartung, H.P., Holmgren, A., Aktas, O., and Berndt, C.
Glutaredoxin 2 protects against oligodendroglial cell death during neuroinflammation.
J. Clinic. Biochem. Nutr. 54: S49 (2014)

Bräutigam, L., Jensen, L.D.E., Poschmann, G., Lepka, K., Montano, S.J., Aktas, O., Stühler, K., Cao, Y., Holmgren, A., and Berndt, C.
Glutaredoxin 2 regulates vascular development by reversible glutathionylation of sirtuin 1.
J. Clinic. Biochem. Nutr. 54: S42 (2014)

Berndt, C., Lepka, K., Volbracht, K., Schneider, R., Hartung, H.P., Prozorovski, T., and Aktas, O.
A vertebrate specific Glutaredoxin affects cellular functions of oligodendrocytes.
Glia 61: S134-S135 (2013)

Schneider R., Bosch, B., Schröter, F., Ingwersen, J., Berndt, C., Hartung, H.P., Prozorovski, T., and Aktas, O.
Differential regulation of the Wnt signaling pathway in experimental autoimmune encephalomyelitis.
Glia 61: S173-S174 (2013)

Berndt, C., Hashemy, S.I., Hudemann, C., Voevodskaya, N., Bill, E., Joseph, B., Edgren, M., Lillig, C.H., Brunk, U.T., and Holmgren, A.
Iron-cofactors in members of the thioredoxin-family of proteins.
Free Rad. Res. 40: S52 (2006)

book chapters

Berndt, C., Wilms, C., Gellert, M., and Lillig, C.H.
Structure-function relationships discriminating between mono- and dithiol Glutaredoxins.

in: „Redox Chemistry and Biology of Thiols“, Alvarez, Comini, Salinas, Eds., Elsevier (2021)

6a-c

Bräutigam, L., and Berndt, C.
Redox regulation during zebrafish development.
Prozorovski, T., Kroll, C., Berndt, C., and Aktas, O.
At the interface between metabolism and redox regulation: Sirtuin 1 as checkpoint for neurogenesis and longevity
Berndt, C., Buchanan, B., Lillig, C.H., and Sies, H.
Redox regulation: A bief historical overview.
all in: „Redox regulation of differentiation and de-differentiation“, Berndt, C./Lillig, C.H., Eds., CRC Press (2021)

Berndt, C., Wilms, C. Thauvin, M., and Vriz, S.
Redox regulated brain development.
in: „Oxidative Stress: Eustress and Distress“, Sies, H., Ed., Elsevier (2020)

Berndt, C.
Zinnteller „Ehrenpreis für bestes Euter“, 130-131
in: „Mensch und Tier im Revier“, Grütter, H.T./Stottrop, U., Eds, Ruhr Museum Essen and Klartext Verlag (2019)

Berndt, C., Engelke, A.D., Bräutigam, L., and Lepka, K.
Glutaredoxins in the brain.
in: „Glutathione Systems in Health and Disease“, Flohé, L., Ed., CRC Press (2018)

Hanschman, E.-M. and Berndt, C.
Thioredoxin.
In: „Encyclopedy of Signaling Molecules“ 2nd edition, Choi, S., Ed., Springer (2018)

Berndt, C.
Leben und Mineralisation, 138-145
in: „Steinreich. Mineralogie im Ruhr Museum“, Scheer, U./Stottrop, U., Eds., Ruhr Museum and Verlag der Buchhandlung Walther König (2014)

C1-3

Berndt, C.
Fokus: Technische Fotosynthese und künstliche Kohle, 66-67 / Focus: Technical
photosynthesis and artificial coal, 66-67
Berndt, C., Stottrop, U.
Berge versetzen – Auswirkungen des Kohleabbaus auf Natur und Landschaft, 292-303 / Moving mountains – effects of coal mining on nature and landscapes, 292-303
Berndt, C.
Fokus: Vielfalt der Proteste, 337-346 / Focus: Diversity of protests, 337-346
all in: „Kohle.Global Eine Reise in die Reviere der anderen“ and „Coal.Global Other coalfields: a journey“, both Stottrop, U., Ed., Ruhr Museum and Klartext Verlag (2013)

B1-4

Berndt, C.
Von Menschen und Tieren, 124-127
Hampel, D.-M., and Berndt, C.
Daten und Fakten, 156-157
Stottrop, U., and Berndt, C.
Naturlandschaft, 178-181
Berndt, C.
Flora und Fauna, 230-233
all in: “Ruhr Museum Natur. Kultur. Geschichte”, Borsdorf, U./Grütter, H.T., Eds., Ruhr Museum and Klartext Verlag (2010)

Lillig, C.H., and Berndt, C.
Thioredoxins and glutaredoxins. Functions and metal ion interactions.
in: “Metal ions in life science” 5, A. Sigel, H. Sigel and R.K.O. Sigel, Eds., The Royal Society of Chemistry, Cambridge, UK, 413-439 (2009)

Berndt, C., and Holmgren, A.
Thioredoxins and the regulation of redox conditions in prokaryotes.
in: “Oxidative folding of cysteine-rich peptides and proteins”, J. Buchner, and L. Moroder, Eds., The Royal Society of Chemistry, Cambridge, UK, 2-18 (2008)

Berndt, C., and Scholten J.
Privates Bier- und Underbergmuseum.
in: “Museumshandbuch Ruhrgebiet Kunst, Kultur und Geschichte”, Grütter, H.T., Ed., Pomp Verlag, Bottrop/Essen (2003)

statistics (google scholar November 2024): citations > 12.500, h-index 45, i10-index 57, ∑ IF > 600