Ferroptosis is a cell death mechanism based on lipid peroxidation and subsequent membrane rupture induced by increased levels of redox active iron and hydrogen peroxide. Glutathione peroxidase 4 is the only mammalian enzyme reducing lipid hydroperoxides to the correponding alcohols. However, many other enzymes and metabolites contribute to anti- and pro-ferroptotic processes. Ferroptosis is linked to several pathological conditions and modulators of ferroptisis are in clinical trials. Our research investigates physiological regulation of this cell death mechanism.

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Berndt, C., Alborzinia, H., Amen, V.S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C.M., Birsoy, K., Böttcher, J.P., Brabletz, S., Brabletz, T., Brown, A.R., Brüne, B., Bulli, G., Bruneau, A., Chen, Q., DeNicola, G.M., Dick, T.P., Distéfano, A., Dixon, S.J., Engler, J.B., Esser-von Bieren, J., Fedorova, M., Friedmann Angeli, J.P., Friese, M.A., Fuhrmann, D.C., García-Sáez, A.J., Garbowicz, K., Götz, M., Gu, W., Hammerich, L., Hassannia, B., Jiang, X., Jeridi, A., Kang, Y.P., Kagan, V.E., Konrad, D.B., Kotschi, S., Lei, P., Le Tertre, M,. Lev, S., Liang, D., Linkermann, A., Lohr, C., Lorenz, S., Luedde, T., Methner, A., Michalke, B., Milton, A.V., Min, J., Mishima, E., Müller, S., Motohashi, H., Muckenthaler, M.U., Murakami, S., Olzmann, J.A., Pagnussat, G., Pan, Z., Papagiannakopoulos, T., Pedrera Puentes, L., Pratt, D.A., Proneth, B., Ramsauer, L., Rodriguez, R., Saito, Y., Schmidt, F., Schmitt, C., Schulze, A., Schwab, A., Schwantes, A., Soula, M., Spitzlberger, B., Stockwell, B.R., Thewes, L., Thorn-Seshold, O., Toyokuni, S., Tonnus, W., Trumpp. A., Vandenabeele, P., Vanden Berghe, T., Venkataramani, V., Vogel, F.C.E., von Karstedt, S., Wang, F., Westermann, F., Wientjens, C., Wilhelm, C., Wölk, M., Wu, K., Yang, X., Yu, F., Zou, Y., and Conrad, M.
Ferroptosis in health and disease.
Redox Biol. 75: 103211 (2024)

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